APO A2 -265T/C Polymorphism Is Associated with Increased Inflammatory Responses in Patients with Type 2 Diabetes Mellitus

BACKGROUND: Apolipoprotein A2 (APO A2) is the second most abundant structural apolipoprotein in high density lipoprotein. Several studies have examined the possible effect of APO A2 on atherosclerosis incidence. Due to the role of inflammation in atherosclerosis, we aimed to determine the relationship between APO A2 -265T/C polymorphism and inflammation as a risk factor in type 2 diabetes mellitus (T2DM) patients. METHODS: In total, 180 T2DM patients, with known APO A2 -265T/C polymorphism, were recruited for this comparative study and were grouped equally based on their genotypes. Dietary intakes, anthropometric parameters, lipid profile, and inflammatory markers (i.e., pentraxin 3 [PTX3], high-sensitivity C-reactive protein [hs-CRP], and interleukin 18) were measured. The data were analyzed using an independent t-test, a chi-square test, and the analysis of covariance. RESULTS: After adjusting for confounding factors, in the entire study population and in the patients with or without obesity, the patients with the CC genotype showed higher hs-CRP (P=0.001, P=0.008, and P=0.01, respectively) and lower PTX3 (P=0.01, P=0.03, and P=0.04, respectively) in comparison with the T allele carriers. In the patients with the CC genotype, no significant differences were observed in the inflammatory markers between the obese or non-obese patients. However, regarding the T allele carriers, the plasma hs-CRP level was significantly higher in the obese patients compared to the non-obese patients (P=0.01). CONCLUSION: In the T2DM patients, the CC genotype could be considered as a risk factor and the T allele as a protective agent against inflammation, which the latter effect might be impaired by obesity. Our results confirmed the anti-atherogenic effect of APO A2, though more studies are required to establish this effect.

Predictors of Dietary Supplement Usage among Medical Interns of Tehran University of Medical Sciences.

This study aimed to determine the prevalence of dietary supplement-use and its relationship with demographics and lifestyle of medical interns. The study sample comprised 356 interns aged 23 to 25 years. Participants completed a questionnaire on dietary supplement-use during the month preceding the study, information on demographic characteristics and lifestyle was also obtained. Univariable and multivariable logistic regression were employed to assess the correlates of dietary supplement-use. The prevalence of dietary supplement-use was about 33% (males 20.4% and females 43.2%, p<0.001). The most commonly-used dietary supplement was multivitamin/multivitamin-mineral (90.6% in males and 52.3% in females). Approximately 30% of supplements were used regularly (≥5 days/week) by all subjects. The most-frequently reported reasons for supplement-use in males were: enhancing daily energy/stamina (51.1%), poor food intake (13.3%) and, in females, were: improving health and nutritional status (39.3%) and reducing hair loss (23.4%). The decision to use dietary supplement was mostly driven by the interns themselves (56% in males, 61% in females). In the univariable analysis, men who exercised once or twice a week were less likely to use supplements compared to those who reported doing exercise more than twice weekly (OR=0.35, 95% CI 0.12-0.98). Females who reported their health status to be ‘excellent’ were more likely to use supplements compared to those who described their health status as ‘moderate/poor/very poor’ (OR=2.53, 95% CI 1.15-5.56) as were women who mentioned their breakfast consumption status as ‘always’ (OR=2.69, 95% CI 1.47-4.92). In the multivariable analysis, only breakfast consumption was significantly related with dietary supplement-use in females (OR=2.20, 95% CI 1.11-4.38). In conclusion, dietary supplement-use among medical interns, especially among females, was relatively very common. Dietary supplement-use was related to a healthier lifestyle.

Comparison of antioxidant status between pilots and non-flight staff of the army force: pilots may need more vitamin C / 生物医学与环境科学（英文）

<p><b>OBJECTIVE</b>To compare the blood antioxidant levels and dietary antioxidant intakes between pilots and non-flight staff of the Army Force in The Islamic Republic of Iran.</p><p><b>METHODS</b>Thirty-seven helicopter pilots and 40 non-flight staff were included in this study. Their general characteristics were recorded and their weight, height, and waist circumference were measured. Their daily intake of energy and nutrients including antioxidants was assessed using a semi-quantitative food frequency questionnaire. Serum levels of total antioxidant capacity (TAC), malondialdehyde (MDA), and glutathione reductase (GR), glutathione peroxidase (GPx), superoxide dismutase (SOD), and catalase (CAT) in red blood cells were also measured.</p><p><b>RESULTS</b>The median erythrocytes SOD, serum MDA level and the mean serum level of TAC and erythrocytes GPx were significantly higher in pilots than in non-flight staff. The median vitamin C intake was significantly lower in pilots than in non-flight staff. The serum MDA levels were similar in non-flight staff and pilots when their vitamin C intake was ⋜168 mg and significantly lower in non-flight staff than in pilots when their vitamin C intake was >168 mg.</p><p><b>CONCLUSION</b>The serum MDA level is lower in non-flight staff than in pilots when their vitamin C intake level is high, indicating that pilots need more vitamin C than non-flight staff.</p>

[Overweight, obesity and some related socio-economic factors among adolescent girls in Tehran, Iran]

To compare obesity, overweight and related socio-economic factors among adolescent girls in the North and South areas of Tehran, the capital of Iran, in 2005. This cross-sectional and analytical study 210 adolescent girls, aged 14-17 years, from high schools in the North area of Tehran [n=105; high socio-economic level] and the South area [n=105; low socio-economic level] were selected by the two-step, cluster random sampling method. Demographic data, including mothers_ and fathers_ educational levels and parents_ jobs were gathered, using a validated self-administered questionnaire. Food intake data were obtained by a one-day 24- hour recall and a one- day food record. Weight and height were measured based on standard methods and Body Mass 85 th >/= Index [BMI] were calculated. Overweight + obesity were defined as a BMI percentile of age - sex specific BMI. The prevalence of overweight +obesity was observed in 15.2% of the girls in the North area and 26.7% of the South area, the difference being significant [P= 0.001]. Mean of energy, fat and energy derived from fat were 1964 kcal, 72.0 gr and 34.1% in North area and 2288 kcal, 83.1 gr and 34.4% in South area, respectively. There was a significant correlation between BMI of the girls and mothers' literacy in the North area. Obesity + overweight were significantly correlated with mothers' job among girls in the South area. Evidence suggests that overweight and obesity in Tehran, especially among female adolescents of a low socioeconomic level, is a public health problem. It is suggested to design and implement nutritional intervention programs for adolescent girls, particularly in the low socio- economic areas

Familial risk factors of obesity in Neishabour school children

To determine obesity familial risk factors in school children in winter 2006. In a cross-sectional study 1471 students aged 6-12 years old selected by two stage cluster sampling. Height and weight of students and their mothers were measured and BMI was calculated. Obesity was defined as having a BMI >/= 95th percentile of Iranian reference. Thereafter, 114 pupils were selected as obese children and the control group was chosen from students having 15th /= 30 kg/m2= obese". Demographic questionnaire was completed by interviewing the mothers. Fifty five percent of obese pupils and 12.9% of control group had overweight mothers [P < 0.001]. There was a significant association between childhood obesity and mothers' age, parental occupation and education [P < 0.001]. Sixty eight percent of obese students had family history of obesity, while only 2.0% of control group had similar background [P < 0.001]. More than 21.1% of obese children were categorized as good economic status, but 2.0% of second group were in this rank. Family size was significantly different in two groups [P < 0.001]. In this study, mothers' obesity, family history of obesity, family size, economic status, mothers' age, parental education and occupation were the risk factors of obesity in Neishabour school children